N-アリル-2-アミノ酢酸誘導体のパラジウム触媒C-H活性化/環化による機能化インドールの一般合成戦略
令和7年2月28日|p.47
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A General Strategy for the Synthesis of Functionalized Indoles via Palladium-Catalyzed C-H Activation/Cyclization of N-Aryl-2-aminoacetates
Yunhe Lv,† Yanyan Li, Tianren Zhu,§ Xiaoxiao Wang,† and Yanxing Jia*,†
†State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
‡School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China
Supporting Information
ABSTRACT: A general strategy for the synthesis of functionalized indoles has been developed through palladium-catalyzed C-H activation/cyclization of N-aryl-2-aminoacetates. This method features a broad substrate scope, good functional group tolerance, and high regioselectivity. The reaction proceeds under mild conditions and provides access to a variety of substituted indoles in moderate to excellent yields.